Welcome to the laboratory of Dr. Rebecca Chin at the City University of Hong Kong. The major goal of our lab is to elucidate signaling pathways perturbed by genetic and epigenetic alterations in breast cancer development and metastasis, with an emphasis on cancer stemness and the identification of novel targets for synthetic lethality strategy. We are particularly interested in triple-negative breast cancer, an aggressive form of breast cancer with poor prognosis. Another major area of our investigation is to explore how PI3K/Akt pathway contributes to therapeutic resistance. The approaches that we are taking including live-cell signaling dynamics, high-throughput proteomics, in vivo Crispr screen, PDO and 3D co-culture system. The ultimate goal of our research is to develop more effective therapies with lower toxicity for cancer patients.