CHIN LAB

FOSL1 is a key regulator of a super-enhancer driving TCOF1 expression in triple-negative breast cancer.

He Q, Hu J, Huang H, Wu T, Li W, Ramakrishnan S, Pan Y, Chan KM, Zhang L, Yang M, Wang X, Chin YR. Epigenetics & Chromatin​, Published online (2024)

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TNA-Mediated Antisense Strategy to Knockdown Akt Genes for Triple-Negative Breast Cancer Therapy.

Li P, Zheng S, Leung HM, Liu LS, Chang TJH, Maryam A, Wang F*, Chin YR*, Lo PK*. Small Methods​, 2400291 (2024)

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Light-activated nanodiamond-based drug delivery systems for spatiotemporal release of antisense oligonucleotides.

Leung HM, Liu LS, Cai Y, Li X, Huang Y, Chu HC, Chin YR, Lo PK. Bioconjugate Chemistry, 35:623 (2024)

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An integrated and multi-functional droplet-based microfluidic platform for digital DNA amplification.

Wang Y, Zhou X, Yang Z, Xu T, Fu H, Fong C-C, Sun J, Chin YR, Zhang L, Guan X, Yang M. Biosensors and Bioelectronics, 246:115831 (2024)

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Distinguishing High-Metastasis-Potential Circulating Tumor Cells through Fluidic Shear Stress in a Bloodstream-Like Microfluidic Circulatory System.

Li W, Guo Z, Zhou Z, Zhou Z, He H, Sun J, Zhou X, Chin YR, Zhang L, Yang M. Oncogene, 43:2295 (2024)

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Akt3 promotes cancer stemness in triple-negative breast cancer through YB1-Snail/Slug signaling axis.

Tian Y, Li J, Cheung TC, Tam V, Lau CG, Wang X, Chin YR. Genes & Diseases​, 10:301 (2023)

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High throughput confined migration microfluidic device for drug screening.

Yang Z, Zhou Z, Si T, Zhou Z, Zhou L, Chin YR, Zhang L, Guan X, Yang M. Small​, 19:e2207194 (2023)

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Three-dimensional Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor-on-a-chip.

Li W, Zhou Z, Zhou X, Khoo BL, Gunawan R, Chin YR, Zhang L, Yi C, Guan X, Yang M. Advanced Healthcare Materials 12:2202609 (2023)

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TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumor growth, and correlates with poor prognosis.

Hu JY, Lai Y, Huang H, Ramakrishnan S, Pan Y, Ma VW, Cheuk W, So GY, He Q, Lau CG, Zhang L, Cho WC, Chan KM, Wang X, Chin YR. British Journal of Cancer, 126:57 (2022) PMID: 34718356

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Upregulation of receptor tyrosine kinase activity and stemness as resistance mechanisms to Akt inhibitors in breast cancer.

Tsang T, He Q, Cohen EB, Stottrup C, Lien EC, Zhang H, Lau CG*, Chin YR*. Cancers​, Published online (2022)

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Cellular Update, Tissue Penetration, Biodistribution, and Biosafety of Threose Nucleic Acids: Assessing In Vitro and In Vivo Delivery.

Wang F, Liu LS, Lau CH, Leung HM, Chin YR, Tin C, Lo PK. Materials Today Bio, 15:100299 (2022) PMID: 35637854

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Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling.

Huang H, Hu J, Maryam A, Huang Q, Zhang Y, Ramakrishnan S, Li J, Ma H, Ma VWS, Cheuk W, So GYK, Wang W, Cho WCS, Zhang L, Chan KM, Wang X*, Chin YR*.  Nature Communications, 12:2242 (2021) PMID: 33854062

• ​Featured in a press release on the CityU website

• Featured in Nature Portfolio Cancer Community

• Media coverage in Hong Kong Economic Times, PChome News, LIFE TW, Taiwan News

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ANLN enhances triple-negative breast cancer stemness through TWIST1 and BMP2 and promotes its spheroid growth.

Maryam A, Chin YR. Frontiers in Molecular Biosciences, 8:700937 (2021) PMID: 34277708​

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Cancer stem cells: advances in biology and clinical translation-a Keystone Symposia report.

Cable J, Pei D, Reid LM, Wang XW, Bhatia S, Karras P, Melenhorst JJ, Grompe M, Lathia JD, Song E, Kuo KJ, Zhang N, White RM, Ma SK, Ma L, Chin YR, Shen MM, Ng IO, Kaestner KH, Zhou L, Sikandar S, Schmitt CA, Guo W, Wong CC, Ji J, Tang DG, Dubrovska A, Yang C, Wiedemeyer WR, Weissman IL. Ann N Y Acad Sci, 1506:142 (2021) PMID: 34850398

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Upregulation of Akt3 confers resistance to Akt inhibitors in breast cancer.

Stottrup C, Tsang T, Chin YR. Mol Cancer Ther, 15:1964 (2016) PMID: 27297869

 

Inhibition of Rb phosphorylation leads to mTORC2-mediated activation of Akt.

Zhang J, Xu K, Liu P, Geng Y, Wang B, Gan W, Guo J, Wu F, Chin YR, Berrios C, Lien EC, Toker A, DeCaprio JA, Sicinski P, Wei W. Mol Cell, 62:929 (2016) PMID: 27237051

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PtdIns(3,4,5)P3-dependent activation of the mTORC2 kinase complex.

Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC,

Toker A, Su B, Wei W. Cancer Discov, 5:1194 (2015) PMID: 26293922 

 

PTEN-deficient tumors depend on Akt2 for maintenance and survival.

Chin YR, Yuan X, Balk SP, Toker A. Cancer Discov, 4:942 (2014) PMID: 24838891

• Cover image of Cancer Discov Vol. 4, Num. 8 issue

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Targeting Akt3 signaling in triple-negative breast cancer.

Chin YR, Yoshida T, Marusyk A, Beck AH, Polyak K, Toker A. Can Res, 74:964

(2014) PMID: 24335962

• Highlighted as a “Very Good” finding by Arthur Mercurio: F1000Prime Biology

 

Akt-ing up on SRPK1: Oncogene or tumor suppressor?

Toker A, Chin YR. Mol Cell, 54:329 (2014) PMID: 24813709

 

RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis.

Kazerounian S, Gerald D, Huang M, Chin YR, Udayakumar D, Zheng N, Oí’Donnell RK, Perruzzi C, Mangiante L, Pourat J, Phung T, Bravo-Nuevo A, Shechter S, McNamara S, DuHadaway J, Kocher ON, Brown L, Toker A, Prendergast GC and Benjamin LE. Can Res, 73:50 (2013) PMID: 23135917

 

Acetylation-Dependent Regulation of Skp2 Function.

Inuzuka H, Gao D, Finley L, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP and Wei W. Cell, 150:179 (2012) PMID: 22770219

 

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.

Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, Harper JW and Wei W. Mol Cell, 44:290 (2011) PMID: 22017875

 

NFAT promotes carcinoma invasive migration through glypican-6.

Yiu GK, Kaunisto A, Chin YR and Toker A. Biochem J, 440:157 (2011) PMID: 21871017

 

Akt isoform-specific signaling in breast cancer: Uncovering an anti-migratory role for palladin.

Chin YR and Toker A. Cell Adh Migr, 5:211 (2011) PMID: 21519185

 

The actin bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration.

Chin YR and Toker A. Mol Cell, 38:333 (2010) PMID: 20471940

• Featured in a press release on the BIDMC website

• Featured in Breast Cancer Network News

• Highlighted as a “Must Read” finding by Brendan Manning: Faculty of 1000 Biology

 

Akt2 regulates expression of the actin-bundling protein palladin.

Chin YR and Toker A. FEBS Lett, 584:4769 (2010) PMID: 21050850

 

Akt/Protein kinase B and glycogen synthase kinase-3β signaling pathway regulates cell migration through the NFAT1 transcription factor.

Yoeli-Lerner M, Chin YR, Hansen CK, and Toker A. Mol Cancer Res 7:425 (2009) PMID: 19258413

 

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APC-Cdh1-mediated Skp2 destruction.

Gao D, Inuzuka H, Tseng A, Chin RY, Toker A, and Wei W. Nat Cell Bio 11:397 (2009) PMID: 19270695

 

 Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer.

Chin YR and Toker A. Cell Signal 21:470 (2009) PMID: 19110052

 

PDK1 potentiates upstream lesions on the PI3K pathway in breast carcinoma.

Maurer M, Su T, Koujak S, Hopkins BD, Saal LH, Barkley CR, Wu J, Nandula S, Dutta B, Xie Y, Chin YR, Kim D, Ferris JS, Gruvberger-Saal SK, LaaksoM, Wang X, Memeo L, Rojtman A, Matos T, Yu JS, Cordon-Cardo C, Isola J, Terry MB, Toker A, Landry DW, Mills GB, Zhao JJ, Murty VV, Hibshoosh H, Parsons R. Can Res 69:6299 (2009) PMID: 19602588

 

The Adenovirus RID complex enhances degradation of internalized tumor necrosis factor receptor 1 without affecting its rate of endocytosis.

Chin YR, and Horwitz MS. J Gen Virol, 87:3161 (2006) PMID: 15542663

 

 Mechanism for removal of TNF receptor 1 from the cell surface by the Adenovirus RIDα/β complex.

Chin YR, and Horwitz MS. J Virol, 79:21 (2005) PMID: 16227281

 

Inhibition of TNF signal transduction by the Adenovirus group C RID complex involves downregulation of surface levels of TNF receptor 1.

Fessler SP, Chin YR, and Horwitz MS. J Virol, 78:23 (2004) PMID: 15542663

 

 High-throughput screening of potential inhibitors for the metabolism of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid.

Zho S, Chiang D, Chin R, Kestell P, Paxton JW. J Chromatogr B Analyt Technol Biomed Life Sci. 767:19 (2002) PMID: 11863291

 

Effects of anticancer drugs on the metabolism of the anticancer drug 5,6-dimethylxanthenone-4-acetic (DMXAA) by human liver microsomes.

Zhou S, Chin R, Kestell P, Tingle MD, Paxton JW. Br J Clin Pharmacol. 52:129. (2001) PMID: 11488768